Brain Connectivity in Depersonalization/Derealization: A New Perspective
Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis
Sisi Zheng, Francis Xiatian Zhang, Hubert P. H. Shum, Haozheng Zhang, Nan Song, Mingkang Song, Hongxiao Jia.
October 2024
Summary:
This study explored brain activity in people with depersonalization-derealization disorder (DDD) using fMRI and a face recognition task. Researchers might have identified key brain networks involved in DDD, including the frontoparietal network, sensorimotor network, and default mode network. They also may have discovered altered brain connectivity patterns, with one pattern differing significantly between those with DDD and healthy individuals. These patterns could be linked to DDD symptoms. Brain stimulation (tDCS) appeared to change some of these patterns in treatment responders.
This research suggests that brain activity, specifically in these networks, might be a useful tool for diagnosing DDD and understanding its symptoms, potentially leading to personalized treatments.