Depersonalization, Mood and Anxiety Disorders

Depersonalization/Derealization and its relationship to mood and anxiety disorders in the National Comorbidity Survey-Replication (NCS-R)
Daphne Simeon & Dan J. Stein

May 2025

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Summary
This study explored the relationship between depersonalization/derealization and mood and anxiety disorders (MAD) using data from the National Comorbidity Survey-Replication (NCS-R). The researchers tried to understand how common these experiences are among people with various mood and anxiety disorders, such as generalized anxiety disorder, panic disorder, social phobia, major depression, and bipolar disorders.

The findings reveal that DDD is more likely to be reported by individuals who have multiple mood and anxiety disorders at the same time. Specifically, 21.2% of those experiencing significant DDD also had mood and anxiety disorders, but only 3.0% of those with mood and anxiety disorders reported experiencing DPDR.